The Role of Oxidative Stress and the Importance of miRNAs as Potential Biomarkers in the Development of Age-Related Macular Degeneration
Description
- Tytuł: The Role of Oxidative Stress and the Importance of miRNAs as Potential Biomarkers in the Development of Age-Related Macular Degeneration
- Autor/Autorzy:
- Nazwa czasopisma: Processes
- Rok: 2021
- ISSN: 2227-9717
- DOI: 10.3390/pr9081328
- Adres www:: https://www.mdpi.com/2227-9717/9/8/1328#cite
- Strony od-do: 1-16
- Język: angielski
- Abstrakt: Age-related macular degeneration (AMD) is the primary cause of blindness in developed countries. With the progressive aging of the population, AMD is a significant ophthalmological problem in the population over 50 years of age. The etiology of AMD is known to be based on various biochemical, immunological and molecular pathways and to be influenced by a range of genetic and environmental elements. This review provides an overview of the pathophysiological role of oxidative stress and free radicals in the retina with a special focus on the DNA repair efficiency and enzymatic antioxidant defense. It also presents a correlation between miRNA profile and AMD, and indicates their involvement in inflammation, angiogenesis, increased oxidation of cellular components, enzymatic antioxidant capacity and DNA repair efficiency, which play particularly important roles in AMD pathogenesis. Gene silencing by miRNAs can induce changes in antioxidant enzymes, leading to a complex interplay between redox imbalance by free radicals and miRNAs in modulating cellular redox homeostasis.
- Dyscyplina: nauki medyczne
MARC
- 002 $a The Role of Oxidative Stress and the Importance of miRNAs as Potential Biomarkers in the Development of Age-Related Macular Degeneration
- 003 $b 0000-0001-8757-6958
- 003 $a Barbara Smigielska (Autor)
- 003 $a EWA KUCHARSKA (Autor)
- 003 $a Ireneusz Majsterek (Autor)
- 003 $a Jacek Szaflik (Autor)
- 003 $a Jerzy Mrowicki (Autor)
- 003 $a Jerzy Szaflik (Autor)
- 003 $a Małgorzata Mrowicka (Autor)
- 004 $a Oryginalny artykuł naukowy
- 006 $a Processes
- 008 $a 2021
- 011 $a 2227-9717
- 013 $a 10.3390/pr9081328
- 014 $a https://www.mdpi.com/2227-9717/9/8/1328#cite
- 015 $a 1-16
- 017 $a angielski
- 020 $a Age-related macular degeneration (AMD) is the primary cause of blindness in developed countries. With the progressive aging of the population, AMD is a significant ophthalmological problem in the population over 50 years of age. The etiology of AMD is known to be based on various biochemical, immunological and molecular pathways and to be influenced by a range of genetic and environmental elements. This review provides an overview of the pathophysiological role of oxidative stress and free radicals in the retina with a special focus on the DNA repair efficiency and enzymatic antioxidant defense. It also presents a correlation between miRNA profile and AMD, and indicates their involvement in inflammation, angiogenesis, increased oxidation of cellular components, enzymatic antioxidant capacity and DNA repair efficiency, which play particularly important roles in AMD pathogenesis. Gene silencing by miRNAs can induce changes in antioxidant enzymes, leading to a complex interplay between redox imbalance by free radicals and miRNAs in modulating cellular redox homeostasis.
- 966 $a nauki medyczne
- 985 $a Wydział Pedagogiczny
- 985 $b Instytut Nauk o Wychowaniu
Dublin Core
Indexes
- Title: The Role of Oxidative Stress and the Importance of miRNAs as Potential Biomarkers in the Development of Age-Related Macular Degeneration
- Author:
- Journal: Processes
- Date: 2021
- Discipline: nauki medyczne
- Structure:
- Language: angielski