Long-term administration of soft drink causes memory impairment and oxidative damage in adult and middle-aged rats

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Tytuł: Long-term administration of soft drink causes memory impairment and oxidative damage in adult and middle-aged rats
Autor/Autorzy:
Nazwa czasopisma: EXPERIMENTAL GERONTOLOGY
Rok: 2022
Tom: 166
ISSN: 0531-5565
e-ISSN: 1873-6815
DOI: 10.1016/j.exger.2022.111873
Adres www:: https://pubmed.ncbi.nlm.nih.gov/35760268/
Strony od-do: 1-9
Język: angielski
Abstrakt: Introduction The consumption of soft drinks has increased considerably in recent decades, mainly cola soft drinks. Excessive consumption of cola-based soft drinks is associated with several diseases and cognitive decline, particularly memory impairment. Furthermore, diets with high sugar can promote insulin resistance, metabolic syndrome, and dyslipidemia. Aim Thus, the present study aimed to evaluate the effect of cola soft drink intake on behavioral alterations and oxidative damage in 2-, 8- and 14- month-old male Wistar rats. Methods The soft drink groups drank soft drink and/or water ad libitum during 67 days, the control groups ingested only water. Radial-arm maze and Y-maze were used to evaluate spatial memory, open-field to evaluate the habituation memory, and inhibitory avoidance to evaluate aversive memory. The behavioral tests started at the day 57 and finished at day 67 of treatment. At 68th day, the rats were killed; frontal cortex and hippocampus were dissected to the analysis of antioxidants enzymes catalase (CAT) and superoxide dismutase (SOD); and the oxidative markers thiobarbituric acid reactive substances (TBARS) and dichloro-dihydro-fluorescein diacetate (DCFH) were measured in the hippocampus. Results and discussion The cola-based soft drink intake caused memory impairment in the radial-arm maze, Y-maze task, and open-field in the 2- and 8-month-old rat, but not in the 14-month-old. There were no difference among groups in the inhibitory avoidance test. In the frontal cortex, soft drink intake reduced CAT activity in the 8-month-old rats and SOD activity in the 8- and 14-month-old rats. In the hippocampus, the soft drink increased CAT activity in 2- and 8-month-old rats, increased DCFH levels at all ages, and increased TBARS levels in 2-month-rats. Therefore, the results show that long-term soft drink intake leads to memory impairment and oxidative stress. The younger seems to be more susceptible to the soft drink alterations on behavior; however, soft drink caused alterations in the oxidative system at all ages evaluated.
Dyscyplina: nauki medyczne

002 $a Long-term administration of soft drink causes memory impairment and oxidative damage in adult and middle-aged rats
003 $b 0000-0001-8757-6958
003 $a Debora Borges Tomaz (Autor)
003 $a Eduarda Behenck Medeiros (Autor)
003 $a Eduardo Pacheco Rico (Autor)
003 $a EWA KUCHARSKA (Autor)
003 $a Francielle Mina (Autor)
003 $a Gabriel Casagrande Zabot (Autor)
003 $a Gustavo Luis Schiavo (Autor)
003 $a Josiane Budni (Autor)
003 $a Karen Vasconcelos Calixto (Autor)
003 $a Maria Manenti Alexandre (Autor)
003 $a Michelle Lima Garcez (Autor)
003 $a Natalia Baltazar do Nascimento (Autor)
003 $a Nathalia de Souza Pereira (Autor)
003 $a Tatiani Bellettini-Santos (Autor)
004 $a Oryginalny artykuł naukowy
006 $a EXPERIMENTAL GERONTOLOGY
008 $a 2022
009 $a 166
011 $a 0531-5565
012 $a 1873-6815
013 $a 10.1016/j.exger.2022.111873
014 $a https://pubmed.ncbi.nlm.nih.gov/35760268/
015 $a 1-9
017 $a angielski
020 $a Introduction The consumption of soft drinks has increased considerably in recent decades, mainly cola soft drinks. Excessive consumption of cola-based soft drinks is associated with several diseases and cognitive decline, particularly memory impairment. Furthermore, diets with high sugar can promote insulin resistance, metabolic syndrome, and dyslipidemia. Aim Thus, the present study aimed to evaluate the effect of cola soft drink intake on behavioral alterations and oxidative damage in 2-, 8- and 14- month-old male Wistar rats. Methods The soft drink groups drank soft drink and/or water ad libitum during 67 days, the control groups ingested only water. Radial-arm maze and Y-maze were used to evaluate spatial memory, open-field to evaluate the habituation memory, and inhibitory avoidance to evaluate aversive memory. The behavioral tests started at the day 57 and finished at day 67 of treatment. At 68th day, the rats were killed; frontal cortex and hippocampus were dissected to the analysis of antioxidants enzymes catalase (CAT) and superoxide dismutase (SOD); and the oxidative markers thiobarbituric acid reactive substances (TBARS) and dichloro-dihydro-fluorescein diacetate (DCFH) were measured in the hippocampus. Results and discussion The cola-based soft drink intake caused memory impairment in the radial-arm maze, Y-maze task, and open-field in the 2- and 8-month-old rat, but not in the 14-month-old. There were no difference among groups in the inhibitory avoidance test. In the frontal cortex, soft drink intake reduced CAT activity in the 8-month-old rats and SOD activity in the 8- and 14-month-old rats. In the hippocampus, the soft drink increased CAT activity in 2- and 8-month-old rats, increased DCFH levels at all ages, and increased TBARS levels in 2-month-rats. Therefore, the results show that long-term soft drink intake leads to memory impairment and oxidative stress. The younger seems to be more susceptible to the soft drink alterations on behavior; however, soft drink caused alterations in the oxidative system at all ages evaluated.
022 $a cola
022 $a memory
022 $a oxidative stress
022 $a rat
022 $a Soft drink
966 $a nauki medyczne
985 $a Wydział Pedagogiczny
985 $b Instytut Nauk o Wychowaniu

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Long-term administration of soft drink causes memory impairment and oxidative damage in adult and middle-aged rats

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Kucharska_Experimental Gerontology.pdf (1.7 MB)