The Modulation of Melanogenesis in B16 Cells Upon Treatment with Plant Extracts and Isolated Plant Compounds
Description
- Tytuł: The Modulation of Melanogenesis in B16 Cells Upon Treatment with Plant Extracts and Isolated Plant Compounds
- Autor/Autorzy:
- Nazwa czasopisma: MOLECULES
- Rok: 2022
- Tom: 27
- Numer: 14
- ISSN: 1420-3049
- e-ISSN: 1420-3049
- DOI: 10.3390/molecules27144360
- Adres www:: https://www.mdpi.com/1420-3049/27/14/4360
- Strony od-do: 1-21
- Język: angielski
- Abstrakt: Plants are a rich source of secondary metabolites that exhibit numerous desired properties. The compounds may influence the biology of melanocytes, pigment cells that produce melanin, by modulating numerous signaling pathways, including cAMP/PKA, MAPKs and PI3K/AKT. Its downstream target is microphthalmia-associated transcription factor, responsible for the expression of the tyrosinase enzyme, which plays a major role in melanogenesis. Therefore, this literature review aims to provide insights related to melanogenesis modulation mechanisms of plant extracts and isolated plant compounds in B16 cells. Database searches were conducted using online-based library search instruments from 2012 to 2022, such as NCBI-PubMed and Google Scholar. Upregulation or downregulation of signaling pathways by phytochemicals can influence skin hypo- and hyperpigmentation by changing the level of melanin production, which may pose a significant cosmetic issue. Therefore, plant extracts or isolated plant compounds may be used in the therapy of pigmentation disorders.
- Dyscyplina: nauki medyczne
MARC
- 002 $a The Modulation of Melanogenesis in B16 Cells Upon Treatment with Plant Extracts and Isolated Plant Compounds
- 003 $b 0000-0001-8757-6958
- 003 $a Anna Merecz-Sadowska (Autor)
- 003 $a EWA KUCHARSKA (Autor)
- 003 $a Karolina Zajdel (Autor)
- 003 $a Przemysław Sitarek (Autor)
- 003 $a Radosław Zajdel (Autor)
- 003 $a Tomasz Kowalczyk (Autor)
- 004 $a Oryginalny artykuł naukowy
- 006 $a MOLECULES
- 008 $a 2022
- 009 $a 27
- 010 $a 14
- 011 $a 1420-3049
- 012 $a 1420-3049
- 013 $a 10.3390/molecules27144360
- 014 $a https://www.mdpi.com/1420-3049/27/14/4360
- 015 $a 1-21
- 017 $a angielski
- 020 $a Plants are a rich source of secondary metabolites that exhibit numerous desired properties. The compounds may influence the biology of melanocytes, pigment cells that produce melanin, by modulating numerous signaling pathways, including cAMP/PKA, MAPKs and PI3K/AKT. Its downstream target is microphthalmia-associated transcription factor, responsible for the expression of the tyrosinase enzyme, which plays a major role in melanogenesis. Therefore, this literature review aims to provide insights related to melanogenesis modulation mechanisms of plant extracts and isolated plant compounds in B16 cells. Database searches were conducted using online-based library search instruments from 2012 to 2022, such as NCBI-PubMed and Google Scholar. Upregulation or downregulation of signaling pathways by phytochemicals can influence skin hypo- and hyperpigmentation by changing the level of melanin production, which may pose a significant cosmetic issue. Therefore, plant extracts or isolated plant compounds may be used in the therapy of pigmentation disorders.
- 022 $a isolated plant compounds
- 022 $a melanogenesis
- 022 $a melanoma cells
- 022 $a plant extracts
- 022 $a signaling pathways
- 966 $a nauki medyczne
- 985 $a Wydział Pedagogiczny
- 985 $b Instytut Nauk o Wychowaniu
Dublin Core
Indexes
- Title: The Modulation of Melanogenesis in B16 Cells Upon Treatment with Plant Extracts and Isolated Plant Compounds
- Author:
- Journal: MOLECULES
- Date: 2022
- Discipline: nauki medyczne
- Structure:
- Language: angielski